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5-Amino-1MQ
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MOTS-C is a 16-amino-acid peptide encoded by mitochondrial DNA, supplied as a 40mg lyophilized research peptide. It is studied for its role in cellular energy metabolism, glucose utilisation, insulin sensitivity and the response of cells to metabolic stress.
MOTS-C (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR. It is encoded within the mitochondrial MT-RNR1 gene, which makes it one of a small group of mitochondrial-derived peptides that act as signalling molecules outside the mitochondria.
It was discovered in 2015 by researchers at the University of Southern California, and it has since become a widely studied peptide in research on metabolism, exercise physiology and ageing.
The discovery study linked MOTS-C to inhibition of the folate cycle and activation of AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance. A later study reported that under metabolic stress MOTS-C moves into the cell nucleus and helps regulate genes involved in the antioxidant response (Kim et al., Cell Metabolism, 2018).
These findings position MOTS-C as a messenger between mitochondria and the rest of the cell, which is why it is studied in models of insulin resistance, obesity and age-related decline in physical function.
The discovery paper reported that MOTS-C targets skeletal muscle and improved insulin sensitivity and prevented diet-induced obesity in mouse models (Lee et al., Cell Metabolism, 2015).
A later study described MOTS-C as an exercise-induced regulator, reporting that its levels rise with exercise and that it improved physical performance in young, middle-aged and older mice (Reynolds et al., Nature Communications, 2021). These are preclinical findings, cited for scientific context only.
Most peptides are encoded by nuclear DNA. MOTS-C is encoded by mitochondrial DNA, so it is studied as a signal through which mitochondria communicate with the rest of the cell and with other tissues.
MOTS-C is available as a 40mg lyophilized powder vial, shipped from Canada.
Store unopened vials in a cool, dry place away from direct light, with refrigeration recommended for long-term storage. After reconstitution, keep the vial refrigerated at 2–8°C.
Published literature is summarised for scientific context only. It is not a claim about this product, and this product is not for human or veterinary use.
Store unopened vials in a cool, dry environment away from direct light. For long-term storage, refrigeration is recommended. After reconstitution, keep refrigerated at 2–8°C and protect from direct light.
Not for human consumption. This product is sold exclusively as a research compound for in vitro and laboratory use by qualified researchers. It is not a drug, supplement, or cosmetic, is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No dosing, administration, or therapeutic claims are made or implied.
Published literature referenced on this page is provided for scientific context only and does not constitute a claim about this product or evidence of safety or efficacy in any organism.
By purchasing this product, you confirm that it will be used for legitimate research purposes in accordance with applicable laws and regulations.
