In Stock
5-Amino-1MQ
50 mg
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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), supplied in 50mg vials. It is studied in research on adipose tissue metabolism, NAD+ pathways and cellular energy regulation.
5-Amino-1MQ is a quinolinium compound: a small molecule rather than a peptide. It belongs to a series of methylquinolinium analogues designed as selective, membrane-permeable inhibitors of nicotinamide N-methyltransferase (NNMT), with a reported half-maximal inhibitory concentration in the low micromolar range.
Its small size and cell permeability make it a useful tool compound for studying what happens inside cells when NNMT activity is reduced.
NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, a form of vitamin B3. The enzyme is highly expressed in the liver and in white adipose tissue, and higher NNMT expression has been associated with obesity and insulin resistance in research models.
Because NNMT consumes both nicotinamide and SAM, its activity can affect the cellular NAD+ salvage pathway and the methylation balance of the cell. Inhibiting NNMT with 5-Amino-1MQ lets researchers study how these linked pathways influence lipid storage and energy expenditure in fat cells.
In the study that introduced this compound series, selective NNMT inhibitors reduced lipogenesis in cultured adipocytes. In mice with diet-induced obesity, a lead inhibitor reduced body weight, white adipose mass and adipocyte size and lowered plasma cholesterol without changing food intake (Neelakantan et al., Biochemical Pharmacology, 2018).
These are preclinical findings, cited for scientific context only.
No. 5-Amino-1MQ is a small-molecule quinolinium compound. It is grouped with research peptides because it is used in the same areas of metabolic research.
5-Amino-1MQ is available in a 50mg vial, shipped from Canada.
Store unopened vials in a cool, dry place away from direct light, with refrigeration recommended for long-term storage. After reconstitution, keep the vial refrigerated at 2–8°C.
Published literature is summarised for scientific context only. It is not a claim about this product, and this product is not for human or veterinary use.
Store unopened vials in a cool, dry environment away from direct light. For long-term storage, refrigeration is recommended. After reconstitution, keep refrigerated at 2–8°C and protect from direct light.
Not for human consumption. This product is sold exclusively as a research compound for in vitro and laboratory use by qualified researchers. It is not a drug, supplement, or cosmetic, is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No dosing, administration, or therapeutic claims are made or implied.
Published literature referenced on this page is provided for scientific context only and does not constitute a claim about this product or evidence of safety or efficacy in any organism.
By purchasing this product, you confirm that it will be used for legitimate research purposes in accordance with applicable laws and regulations.
