KLOW

What is KLOW?

KLOW is a four-peptide research blend that brings together compounds studied in different parts of the tissue-repair process. It contains GHK-Cu (50mg), a copper-binding tripeptide; BPC-157 (10mg), a 15-amino-acid gastric peptide fragment; TB-500 (10mg), synthetic thymosin beta-4; and KPV (10mg), an anti-inflammatory tripeptide derived from α-MSH.

The blend extends the BPC-157 + TB-500 combination with GHK-Cu and KPV, letting researchers study four complementary pathways in the same experimental model.

How the components work

GHK-Cu is studied for collagen and extracellular matrix synthesis and for its broad effects on gene expression. BPC-157 is studied in tendon, ligament and gastrointestinal injury models, with proposed effects on angiogenesis and nitric oxide signalling.

TB-500 (thymosin beta-4) regulates actin and is linked to cell migration and survival after injury. KPV, the C-terminal tripeptide of α-MSH, is studied for its effects on inflammatory signalling, including in models of intestinal inflammation.

What published research has examined

Each component has its own research literature: GHK-Cu in tissue remodelling and gene expression (Pickart and Margolina, 2018), BPC-157 in tendon healing (Staresinic et al., 2003), thymosin beta-4 in cell migration and cardiac repair (Bock-Marquette et al., 2004) and KPV in intestinal inflammation (Dalmasso et al., 2008).

Published studies of the four-peptide combination itself are limited, so the blend is mainly of interest for research into how these pathways interact. This literature is cited for scientific context only.

Key research areas

• Collagen synthesis and extracellular matrix remodelling
• Wound repair and tissue regeneration models
• Actin regulation and cell migration
• Angiogenesis
• Inflammatory signalling and epithelial tissue models

KLOW FAQ

What is in KLOW?

Each 80mg vial contains GHK-Cu 50mg, BPC-157 10mg, TB-500 10mg and KPV 10mg.

How is KLOW different from BPC-157 + TB-500?

BPC-157 + TB-500 contains two peptides. KLOW adds GHK-Cu and KPV, so it covers collagen and matrix remodelling and inflammatory signalling as well as the repair pathways of BPC-157 and TB-500.

How should KLOW be stored?

Store unopened vials in a cool, dry place away from direct light, with refrigeration recommended for long-term storage. After reconstitution, keep the vial refrigerated at 2–8°C.

References

1. Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2018;19(7):1987. DOI
2. Staresinic M, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon. J Orthop Res. 2003;21(6):976–983. DOI
3. Bock-Marquette I, et al. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432:466–472. DOI
4. Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166–178. DOI

Published literature is summarised for scientific context only. It is not a claim about this product, and this product is not for human or veterinary use.